Treatment-Resistant Depression: Conference Sessions

Maurizio Fava

Sequenced strategies for depression that has not responded to standard antidepressant trials.

Adrian Preda

Advanced pharmacologic and interventional options for depression unresponsive to first-line treatment.

Ketamine & EsketamineNeuromodulation (ECT, TMS)

Adrian Preda

Advanced strategies for managing patients with treatment-resistant depression.

Rana Elmaghraby

A talk within a symposium on depression in neurodiverse and gender-variant youth, covering accelerated theta burst stimulation for treatment-resistant depression in autistic youth, from open-label findings toward a randomized controlled trial.

Autism & Neurodevelopmental DisordersChild & AdolescentNeuromodulation (ECT, TMS)

Rana Elmaghraby · Ernest Pedapati · Donald L. Gilbert · Fenil Patel

Randomized trial results on accelerated theta burst stimulation for treatment-resistant depression in autistic patients, covering clinical, cognitive and EEG outcomes.

Autism & Neurodevelopmental DisordersNeuromodulation (ECT, TMS)

Paul E. Croarkin

A clinical consultation breakfast reviewing evidence, safety, regulatory and ethical issues for TMS, ECT, electrical stimulation, ketamine/esketamine and emerging psychedelic approaches in youth with treatment-resistant disorders. Uses case-based discussion on patient selection and consent/assent.

Child & AdolescentKetamine & EsketamineNeuromodulation (ECT, TMS)

Amy Berg · Carol Kottwitz

Evidence-informed strategies for optimizing care when depression fails to remit with standard treatments.

Courtney Miller · Paula Bolton · Jonathan Foley

Two published ketamine clinic studies: memory effects of treatment and IV versus intranasal efficacy comparison.

Ketamine & Esketamine

Stephen M. Stahl

Treatment strategies for depression that has not responded to standard approaches.

Scott Aaronson

Where psychedelic-assisted treatment stands for severe treatment-resistant depression, from trial evidence to practical considerations.

Psychedelics

Roel Mocking · Iris Dalhuisen · Annemiek Dols · Victoria Stiglbauer

Interactive course working through difficult-to-treat OCD and depression cases with neuromodulation approaches.

Neuromodulation (ECT, TMS)OCD & Related Disorders

Yvan Vachez · Katya Rubia · Odile van den Heuvel · Christine Reif-Leonhard

DBS, trigeminal nerve stimulation in ADHD, rTMS-augmented exposure therapy for OCD, and implantable VNS for difficult-to-treat depression.

ADHDNeuromodulation (ECT, TMS)OCD & Related Disorders

Michael Ziller · Esmée Verwijk · Alessandra Minelli · Koen Demyttenaere

iPSC models, pharmacogenomics, ECT cognitive effects, and lived-experience perspectives on treatment resistance.

Neuromodulation (ECT, TMS)Neuroscience & MechanismsPharmacogenomics & Precision Psychiatry

Neuromodulation (ECT, TMS)

Brittany Albright · Michael Asbach

Examines glutamatergic dysfunction in MDD and the evidence for current and emerging glutamate-targeting therapies in treatment-resistant depression.

Ketamine & EsketamineNeuroscience & Mechanisms

Brittany Albright · Rebecca Barbee · Kristian Dambrino

Case-based walkthrough of evaluating apparent treatment resistance in MDD — uncovering hidden contributors like anxiety, trauma, and medical illness — and choosing among optimization, augmentation, and switching pathways.

Depression

Lisa Harding · Michael Asbach

Four case scenarios guide selection among TMS, ECT, VNS, theta-burst, and accelerated protocols, comparing mechanisms, indications, and sequencing within overall treatment plans.

DepressionNeuromodulation (ECT, TMS)

Mark Zimmerman · Shelley Matthews

Advanced review of switching protocols, cross-tapering, and augmentation options — lithium, T3, atypicals, dextromethorphan/bupropion, vortioxetine — for patients with incomplete antidepressant response.

DepressionLithium & Mood StabilizersNovel Antidepressants